Remove the suppository from the outer white wrapper. You should use a water-soluble lubricant such as KY or Surgilube to ease insertion and insure ease of entry. Vaseline (Petroleum Jelly) should NEVER be used as it is barrier between the active ingredient and the bowel. Remove the suppository from the outer white wrapper. You should use a water-soluble lubricant such as KY or Surgilube to ease insertion and insure ease of entry. Vaseline (Petroleum Jelly) should NEVER be used as it is barrier between the active ingredient and the bowel.